Protective Effects of Alpha Lipoic Acid on Cerebral Vasospasm in Rats
نویسندگان
چکیده
منابع مشابه
The effects of alpha lipoic acid on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit.
AIM The aim of this study is to determine the effects of a strong dithiol antioxidant, alpha lipoic acid (ALA) on cerebral vasospasm following subarachnoid hemorrhage in a rabbit model. MATERIAL AND METHODS Twenty-one New Zealand white rabbits were assigned to one of three groups: group 1 (control), group 2 (SAH only), group 3 (SAH+ALA). ALA was administered (100 mg/kg/day, ...
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BACKGROUND Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). AIMS The aim of this study was to investigate the possible protective role of alpha-lipoic acid (α-LA) on oleic acid (OA)-induced ALI in rats. STUDY DESIGN Animal experiment. METHODS A total of thirty-five rats were divided into five groups in the study. Group 1 served as a co...
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PURPOSE Radiation therapy is a treatment for patients with head and neck (HN) cancer. However, radiation exposure to the HN often induces salivary gland (SG) dysfunction. We investigated the effect of α-lipoic acid (ALA) on radiation-induced SG injury in rats. RESULTS ALA preserved acinoductal integrity and acinar cell secretary function following irradiation. These results are related to the...
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Lipopolysaccharide (LPS) is a major cell wall component of gram-negative bacteria known to stimulate the synthesis and secretion of several toxic metabolites, such as reactive oxygen species and cytokines. In this study, the protective effect of alpha-lipoic acid (ALA) and coenzyme Q10 (CoQ10) were evaluated in LPS-induced hepatic injury in rats. To this end, male adult Sprague Dawley rats were...
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Carbon tetrachloride (CCl4) is a well known toxicant and exposure to this chemical is known to induce oxidative stress by the formation of free radicals. The present study investigates the in vivo effects of alpha lipoic acid (ALA) on CCl4-induced hepatic and renal toxicities. Twenty-four Sprague-Dawley rats were divided into four groups of 6 animals each and treated for 10 consecutive days. Gr...
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ژورنال
عنوان ژورنال: Southern Clinics of Istanbul Eurasia
سال: 2020
ISSN: 2587-0998
DOI: 10.14744/scie.2020.28863